[慢性粒细胞白血病急变期白细胞的某些生化特征]
[Certain biochemical features of leukocytes in blast crisis of chronic myelogenous leukemia].
作者信息
Kharchenko M F, Rybakova L P, Filanovskaia L I, Saltykova L B, Bitiukova E S, Shcherbakova E G, Rukavitsyn O A, Bessmel'tsev S S, Abdulkadyrov K M, Blinov M M
机构信息
Russian Research Institute of Hematology and Transfusiology, St. Petersburg.
出版信息
Vopr Med Khim. 1998 May-Jun;44(3):274-80.
The content of nuclear high mobility group (HMG) proteins, activities of ornithine decarboxylase (ODC), adenosine deaminase (ADA) and purine nucleoside phosphorylase (PNP) and also glycosaminoglycan (GAG) content and composition were studied in leukocytes of patients with chronic myelogenous leukemia in the phase of blast crisis (BC CML). Myeloid and lymphoid cytochemical variants of BC CML differ by biochemical parameters. It is suggested, that the content of HMG-proteins, activities of ODC and PNP, and electrophoretic patterns of GAGs could be used in diagnostics of two main variants of BC CML.
对处于急变期（BC CML）的慢性粒细胞白血病患者白细胞中的核高迁移率族（HMG）蛋白含量、鸟氨酸脱羧酶（ODC）、腺苷脱氨酶（ADA）和嘌呤核苷磷酸化酶（PNP）活性以及糖胺聚糖（GAG）含量和组成进行了研究。BC CML的髓系和淋巴系细胞化学变体在生化参数上存在差异。有人提出，HMG蛋白含量、ODC和PNP活性以及GAG的电泳图谱可用于诊断BC CML的两种主要变体。
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