Imamoto H, Yamazaki K, Kan K, Hirao T, Fukunaga M, Tono T, Ohzato H, Maruyama H, Hasegawa S, Kondou M, Kim Y, Takatsuka Y
Dept. of Surgery, Kansai Rosai Hospital.
Gan To Kagaku Ryoho. 1998 Jul;25(9):1419-21.
We experienced a case of multiple liver metastasis from postoperative gastric cancer who showed long-term survival with hepatic arterial infusion chemotherapy (HAI) of MMC and pirarubicin. A catheter was inserted into the hepatic artery, and 4 mg of MMC and 20 mg of pirarubicin were administered through an implantable port catheter every two to four weeks. The total dose of MMC and pirarubicin by the time of this report was 164 mg and 820 mg, respectively. The follow-up CT scan 2 months after the beginning of HAI showed a decrement of the liver tumors. The decrease rate at 12 and 17 months was 50% and 70%, respectively, which was diagnosed as partial response (PR). The therapeutic effect at 49 months is still PR without any sign of tumor enlargement of extra hepatic lesion.
我们遇到一例术后胃癌多发肝转移患者，通过丝裂霉素（MMC）和吡柔比星肝动脉灌注化疗（HAI）实现了长期生存。将导管插入肝动脉，每两到四周通过植入式端口导管给予4mg MMC和20mg吡柔比星。至本报告时，MMC和吡柔比星的总剂量分别为164mg和820mg。HAI开始2个月后的随访CT扫描显示肝肿瘤缩小。12个月和17个月时的缩小率分别为50%和70%，被诊断为部分缓解（PR）。49个月时的治疗效果仍为PR，无肝外病变肿瘤增大的迹象。
