镰状细胞病中纤连蛋白P1和III型前胶原氨基末端前肽的血清浓度。
Serum concentrations of laminin P1 and aminoterminal propeptide of type III procollagen in sickle cell disease.
作者信息
Bolarin D M, Swerdlow P, Wallace A M, Littsey L
机构信息
Department of Chemical Pathology, College of Medical Sciences, University of Calabar, Nigeria.
出版信息
Haematologia (Budap). 1998;29(1):51-8.
We determined serum levels of laminin and aminoterminal propeptide of type III procollagen (PIIINP) in 20 patients with sickle cell hemoglobinopathies. Elevated levels of soluble laminin and PIIINP were observed in the patients--1.5 +/- 0.3 U/ml (mean +/- SD) (range 1.1-1.9 U/ml) and 0.90 +/- 0.2 U/ml (range 0.6-1.4 U/ml), respectively, compared to normal controls, 1.3 +/- 0.1 U/ml (range 1.2-1.4 U/ml) for laminin and 0.7 +/- 0.1 U/ml (range 0.6-0.9 U/ml) for PIIINP. The serum laminin and PIIINP were significantly elevated (p < 0.02 and p < 0.001, respectively, in patients with sickle cell hemoglobinopathies). There was no correlation between serum laminin and PIIINP levels in the patient group. The study indicates that aminoterminal propeptide of type III procollagen and laminin can be utilized as valuable non-invasive markers of possible alterations in extracellular matrix in bone marrow, spleen, kidney or other tissues in sickle cell hemoglobinopathies.
我们测定了20例镰状细胞血红蛋白病患者血清层粘连蛋白和III型前胶原氨基端前肽（PIIINP）的水平。与正常对照组相比，患者的可溶性层粘连蛋白和PIIINP水平升高，层粘连蛋白分别为1.5±0.3 U/ml（均值±标准差）（范围1.1 - 1.9 U/ml），PIIINP为0.90±0.2 U/ml（范围0.6 - 1.4 U/ml），正常对照组层粘连蛋白为1.3±0.1 U/ml（范围1.2 - 1.4 U/ml），PIIINP为0.7±0.1 U/ml（范围0.6 - 0.9 U/ml）。镰状细胞血红蛋白病患者血清层粘连蛋白和PIIINP显著升高（分别为p < 0.02和p < 0.001）。患者组血清层粘连蛋白和PIIINP水平之间无相关性。该研究表明，III型前胶原氨基端前肽和层粘连蛋白可作为镰状细胞血红蛋白病患者骨髓、脾脏、肾脏或其他组织细胞外基质可能改变的有价值的非侵入性标志物。
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