Kincade P W, Yamashita Y, Borghesi L, Medina K, Oritani K
Oklahoma Medical Research Foundation, Oklahoma City 73104, USA.
Vox Sang. 1998;74 Suppl 2:265-8. doi: 10.1111/j.1423-0410.1998.tb05430.x.
New molecular approaches are rapidly yielding information about the composition of bone marrow and culture studies suggest possible functions for many molecules in that organ. However, the marrow is extraordinarily complex with respect to interactions between cells and their behaviour may not be adequately modeled in culture. It is becoming apparent that post-translational modifications and function of proteins can be highly influenced by the cellular and extracellular environment. Therefore, in vivo studies will continue to be important for understanding this remarkable organ.
新的分子方法正在迅速提供有关骨髓组成的信息，培养研究表明该器官中许多分子可能具有的功能。然而，骨髓在细胞间相互作用方面极其复杂，其细胞行为在培养中可能无法得到充分模拟。越来越明显的是，蛋白质的翻译后修饰和功能会受到细胞内和细胞外环境的高度影响。因此，体内研究对于了解这个非凡的器官仍将至关重要。
