Arruda J A, Westenfelder C, Lockwood R, Kurtzman N A
Am J Physiol. 1976 Sep;231(3):749-53. doi: 10.1152/ajplegacy.1976.231.3.749.
Glucose and bicarbonate reabsorption were studied in dogs made edematour by aortocaval fistula (A-V dogs) and in sham-operated dogs. Following construction of the A-V fistula, there was a significant increase in body weight; glomerular filtration rate, renal plasma flow, hematocrit, and sodium excretion decreased significantly. Bicarbonate reabosorption was significantly higher in A-V than in sham dogs both during control and volume expansion. Volume expansion depressed bicarbonate reabsorption significantly in both groups. Glucose reabsorption fell following volume expansion in both groups; glucose reabsorption was significantly higher in A-V dogs than in sham dogs during control and volume expansion. Volume expansion led to a minimal increase in sodium excretion in A-V dogs when compared to the increase in the sham dogs. These data demonsttate that chronic sodium retention is associated with enhanced reabsorption of glucose and bicarbonate. The site in the neophron responsible for the increase in reabsorption of these substances cannot be determined with certainty based on these clearance studies although it is possible that proximal reabsorption may be enhanced in this model.
对通过主动脉腔静脉瘘造成水肿的犬（动静脉瘘犬）和假手术犬的葡萄糖和碳酸氢盐重吸收情况进行了研究。建立动静脉瘘后，体重显著增加；肾小球滤过率、肾血浆流量、血细胞比容和钠排泄量显著降低。在对照期和容量扩张期，动静脉瘘犬的碳酸氢盐重吸收均显著高于假手术犬。容量扩张使两组的碳酸氢盐重吸收均显著降低。两组容量扩张后葡萄糖重吸收均下降；在对照期和容量扩张期，动静脉瘘犬的葡萄糖重吸收均显著高于假手术犬。与假手术犬相比，容量扩张使动静脉瘘犬的钠排泄量增加幅度最小。这些数据表明，慢性钠潴留与葡萄糖和碳酸氢盐重吸收增强有关。尽管在此模型中近端重吸收可能增强，但根据这些清除率研究尚不能确定肾单位中负责这些物质重吸收增加的部位。
