Yazdani S, Simon A D, Vidhun R, Gulotta C, Schwartz A, Rabbani L E
Division of Cardiology, Department of Medicine, Columbia-Presbyterian Medical Center, New York, NY, USA.
Am Heart J. 1998 Aug;136(2):357-61. doi: 10.1053/hj.1998.v136.90408.
Inflammatory markers have been shown to be elevated in acute coronary syndromes. Recently, interleukin-6 was demonstrated to be elevated in unstable angina compared with stable angina. However, the effect of percutaneous coronary interventions on the levels of inflammatory markers is less well known.
In this study, we measured the levels of interleukin-6 and interleukin-1 by using enzyme-linked immunosorbent assays in patients with angina pectoris undergoing coronary interventions and in healthy control subjects. Interleukin-6 was significantly elevated in patients with unstable angina compared with patients with stable angina (P= .01). There were no significant differences between the levels of interleukin-1 in patients with unstable angina versus patients with stable angina and healthy control subjects. Furthermore, at 1-month follow-up after percutaneous coronary interventions, there were no longer any significant differences between the levels of interleukin-6 in patients with unstable angina versus patients with stable angina and healthy control subjects.
These data suggest that interleukin-6 levels may correlate with instability of atheromatous plaques and that the decrease of interleukin-6 levels after percutaneous coronary interventions may represent plaque reendothelialization and stabilization.
炎症标志物在急性冠脉综合征中已被证明会升高。最近，与稳定型心绞痛相比，白细胞介素-6在不稳定型心绞痛中被证明会升高。然而，经皮冠状动脉介入治疗对炎症标志物水平的影响尚鲜为人知。
在本研究中，我们采用酶联免疫吸附测定法，对接受冠状动脉介入治疗的心绞痛患者和健康对照者的白细胞介素-6和白细胞介素-1水平进行了测量。与稳定型心绞痛患者相比，不稳定型心绞痛患者的白细胞介素-６水平显著升高（P = 0.01）。不稳定型心绞痛患者与稳定型心绞痛患者及健康对照者的白细胞介素-1水平无显著差异。此外，在经皮冠状动脉介入治疗后的1个月随访中，不稳定型心绞痛患者与稳定型心绞痛患者及健康对照者的白细胞介素-6水平不再有任何显著差异。
这些数据表明，白细胞介素-６水平可能与动脉粥样硬化斑块的不稳定性相关，且经皮冠状动脉介入治疗后白细胞介素-６水平的降低可能代表斑块的再内皮化和稳定。
