Kakourou T, Theodoridou M, Mostrou G, Syriopoulou V, Papadogeorgaki H, Constantopoulos A
First Department of Pediatrics, Athens University, Greece.
J Am Acad Dermatol. 1998 Aug;39(2 Pt 1):207-10. doi: 10.1016/s0190-9622(98)70076-3.
The clinical studies of series of children with herpes zoster (HZ) are rather limited.
The purpose of this study was to evaluate the epidemiologic conditions, clinical manifestations, therapy, and outcome of HZ in children.
Twenty-one patients with HZ have been studied. Five patients who had herpes simplex virus infection were excluded. The laboratory diagnosis was made by fluorescent techniques. Acyclovir was administered systematically for 2 more days after no new lesions had developed.
Thirteen patients (group A) were immunocompromised; eight patients (group B) were otherwise healthy. Two patients from group B had intrauterine varicella; the other six patients had had varicella under the age of 4 years. Three patients were recently exposed to varicella. The duration of HZ was significantly longer in group A than in group B, but the outcome was good in all patients.
Herpes simplex virus infection may simulate the pattern of HZ; varicella in early childhood is a risk factor for HZ in otherwise healthy children; exposure of a child to varicella may cause reactivation of latent HZ virus; and acyclovir therapy within 3 days of exanthem onset prevents significant morbidity and death in immunocompromised children with HZ.
关于儿童带状疱疹（HZ）系列的临床研究相当有限。
本研究旨在评估儿童HZ的流行病学情况、临床表现、治疗及预后。
对21例HZ患者进行了研究。排除了5例单纯疱疹病毒感染患者。通过荧光技术进行实验室诊断。在没有新皮疹出现后，阿昔洛韦系统给药2天。
13例患者（A组）免疫功能低下；8例患者（B组）健康状况良好。B组中有2例患者有宫内水痘感染；其他6例患者在4岁前患过水痘。3例患者近期接触过水痘。A组HZ病程明显长于B组，但所有患者预后良好。
单纯疱疹病毒感染可能模拟HZ的表现；幼儿期患水痘是健康儿童患HZ的一个危险因素；儿童接触水痘可能导致潜伏的HZ病毒激活；在皮疹出现后3天内进行阿昔洛韦治疗可预防免疫功能低下的HZ儿童出现严重发病和死亡。
