Craven J, Bjørn H, Henriksen S A, Nansen P, Larsen M, Lendal S
Danish Veterinary Laboratory, Copenhagen V.
Equine Vet J. 1998 Jul;30(4):289-93. doi: 10.1111/j.2042-3306.1998.tb04099.x.
This study reports on the prevalence of anthelmintic resistance in strongyles of horses in Denmark. Of 5 methods used for the calculation of faecal egg count reduction (FECR) the method recommended by the World Association for the Advancement of Veterinary Parasitology, for the detection of resistance in sheep was the most sensitive procedure for detecting resistance. Using this method benzimidazole resistance was detected on 33 of 42 farms (79%) examined. Pyrantel was tested on 15 farms and FECR tests indicate resistance on 3 (30%) farms. On 2 farms on which resistance to pyrantel was detected resistance to benzimidazoles was also detected. On one of 16 farms examined ivermectin resistance was indicated at Day 14 but not at Day 19. On the 15 remaining farms ivermectin was effective. Due to the high prevalence of anthelmintic resistance in Danish horse herds it is recommended that tests of anthelmintic efficacy be conducted routinely to monitor the effectiveness of the strongyle control programmes.
本研究报告了丹麦马匹圆线虫体内抗驱虫药的流行情况。在用于计算粪便虫卵计数减少率（FECR）的5种方法中，世界兽医寄生虫学促进会推荐的用于检测绵羊抗药性的方法是检测抗药性最敏感的程序。使用该方法，在42个受检农场中的33个（79%）检测到苯并咪唑抗药性。在15个农场对噻嘧啶进行了测试，FECR测试表明3个（30%）农场存在抗药性。在检测到对噻嘧啶有抗药性的2个农场中，也检测到了对苯并咪唑的抗药性。在16个受检农场中的1个，第14天显示有伊维菌素抗药性，但第19天未显示。在其余15个农场中，伊维菌素有效。由于丹麦马群中抗驱虫药的高流行率，建议定期进行驱虫药疗效测试，以监测圆线虫控制计划的有效性。
