荷兰马圆线虫抗驱虫药的流行情况。

The prevalence of anthelmintic resistance of horse strongyles in The Netherlands.

作者信息

Boersema J H, Borgsteede F H, Eysker M, Elema T E, Gaasenbeek C P, van der Burg W P

机构信息

Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, University of Utrecht, The Netherlands.

出版信息

Vet Q. 1991 Oct;13(4):209-17. doi: 10.1080/01652176.1991.9694310.

DOI:10.1080/01652176.1991.9694310

PMID:1776235

Abstract

A survey to determine the prevalence of anthelmintic resistance of horse strongyles was carried out with 616 horses on 22 farms. The tested drugs were cambendazole, pyrantel pamaote and ivermectin. Based on egg count reduction tests the efficacy of cambendazole varied from 0% to 93% and of pyrantel from 93% to 100%. Ivermectin treatments were 100% effective on all farms. Larval cultures after cambendazole treatments revealed exclusively cyathostome larvae. After pyrantel treatments besides cyathostome larvae other types of larvae were also found. After ivermectin treatments only a few cyathostome larvae were observed. It can be concluded that benzimidazoleresistance of cyathostomes is very common and widespread in the Netherlands. This means that benzimidazoles and pro-benzimidazoles should be excluded for strategic use in horses.

摘要

对22个农场的616匹马进行了一项调查，以确定马圆线虫抗驱虫药的流行情况。所测试的药物为坎苯达唑、噻嘧啶和伊维菌素。根据虫卵计数减少试验，坎苯达唑的疗效在0%至93%之间，噻嘧啶的疗效在93%至100%之间。伊维菌素治疗在所有农场均100%有效。坎苯达唑治疗后的幼虫培养仅发现杯状环体幼虫。噻嘧啶治疗后，除杯状环体幼虫外，还发现了其他类型的幼虫。伊维菌素治疗后仅观察到少数杯状环体幼虫。可以得出结论，杯状环体线虫对苯并咪唑类药物的耐药性在荷兰非常普遍且广泛存在。这意味着应排除苯并咪唑类药物和前体苯并咪唑类药物在马匹中的战略使用。