Krunic A L, Garrod D R, Hunter J A, Clark R E
Division of Dermatology, Duke University Medical Center, Durham, North Carolina 27710, USA.
Arch Dermatol Res. 1998 Jun;290(6):319-24. doi: 10.1007/s004030050311.
Multiple self-healing squamous cell epithelioma of the skin (MSSE) is the most common variant of multiple keratoacanthoma. Although the morphology of the lesions in MSSE is similar to classical actinic keratoacanthoma (KA), several distinctive features in clinical presentation and histology have been emphasized. Desmosomes have been shown to be downregulated in certain types of carcinoma. Desmogleins (Dsg) are transmembrane desmosomal glycoproteins that exist as three isoforms. Dsg markers have been found to be reduced or absent in squamous cell carcinoma (SCC) but preserved in KA.
This study was designed to determine the pattern of Dsg staining in MSSE.
Eight tumors from two female patients with MSSE were stained with the antidesmoglein monoclonal antibody 32-2B, which recognizes Dsgl and Dsg3.
All eight tumors showed uniform pericellular Dsg staining throughout the nonkeratinized layers of the neoplastic epithelium. This pattern is entirely similar to that observed in actinic KA, normal epidermis or follicular epithelium.
Despite the differences, uniform preservation of Dsg seems to be the invariable feature of both MSSE and KA. Further studies are necessary to evaluate this antibody in routine dermatopathology of MSSE and SCC.
皮肤多发性自愈性鳞状细胞上皮瘤（MSSE）是多发性角化棘皮瘤最常见的变体。尽管MSSE病变的形态与经典光化性角化棘皮瘤（KA）相似，但在临床表现和组织学方面有几个显著特征。桥粒在某些类型的癌中已被证明表达下调。桥粒芯糖蛋白（Dsg）是跨膜桥粒糖蛋白，有三种异构体。已发现Dsg标记物在鳞状细胞癌（SCC）中减少或缺失，但在KA中保留。
本研究旨在确定MSSE中Dsg染色模式。
用识别Dsg1和Dsg3的抗桥粒芯糖蛋白单克隆抗体32-2B对两名患有MSSE的女性患者的8个肿瘤进行染色。
所有8个肿瘤在肿瘤上皮的非角质化层中均显示出均匀的细胞周围Dsg染色。这种模式与在光化性KA、正常表皮或毛囊上皮中观察到的完全相似。
尽管存在差异，但Dsg的均匀保留似乎是MSSE和KA的不变特征。有必要进一步研究以评估该抗体在MSSE和SCC常规皮肤病理学中的应用。
