van der Sanden G A, Schouten L J, van Dijck J A, van Andel J P, Coebergh J
Comprehensive Cancer Center South (IKZ), Eindhoven, The Netherlands.
Neuroepidemiology. 1998;17(5):247-57. doi: 10.1159/000026177.
About 2,000 patients with primary CNS cancers, as defined by the ICD-O, were registered in four adjacent cancer registries in South and East Netherlands in 1989-1994, covering a population of more than 5 million people. About 85% of the patients were registered through pathological laboratories, concentrated in four centers for neurosurgery. Patients with a clinical-radiological diagnosis only (about 50% in the age-group of 75 years and older) were mainly identified through medical records of hospitalized patients. World-standardized incidence rates of 6.5 and 4.4 per 100,000 person-years for males and females, respectively, were similar to those reported in other European cancer registries. Eighty-five percent of histologically verified primary CNS cancers were of glial origin, 6% were lymphomas and 4% embryonal tumors. Gliomas were mainly of astrocytic (about 85%) and oligodendroglial or mixed type (about 10%). Without additional review most astrocytic tumors could be classified into high-grade (70-75%) and low-grade astrocytomas (20-25%). Different grading systems were used for gliomas, but the dichotomy of astrocytomas according to differentiation grade seemed to correspond well with the definition of the WHO. Age-specific incidence rates for low-grade astrocytomas were remarkably constant. The incidence of high-grade astrocytomas increased sharply with age and declined after the age of 70, whereas the incidence of clinically diagnosed tumors continued to increase. Male/females-ratios were relatively high for these tumor types (1. 6-1.7). We conclude that the registration of primary CNS cancers in the Netherlands may be almost complete and valid for gliomas, embryonal tumors and lymphomas.
1989年至1994年期间，按照国际疾病分类肿瘤学（ICD - O）定义，荷兰南部和东部四个相邻癌症登记处登记了约2000例原发性中枢神经系统癌症患者，覆盖人口超过500万。约85%的患者通过病理实验室登记，集中在四个神经外科中心。仅通过临床放射学诊断的患者（75岁及以上年龄组中约占50%）主要通过住院患者病历识别。男性和女性的世界标准化发病率分别为每10万人年6.5例和4.4例，与其他欧洲癌症登记处报告的发病率相似。经组织学证实的原发性中枢神经系统癌症中，85%起源于神经胶质细胞，6%为淋巴瘤，4%为胚胎性肿瘤。胶质瘤主要为星形细胞型（约85%）和少突胶质细胞型或混合型（约10%）。未经额外复查，大多数星形细胞瘤可分为高级别（70 - 75%）和低级别星形细胞瘤（20 - 25%）。胶质瘤采用了不同的分级系统，但根据分化程度对星形细胞瘤进行的二分法似乎与世界卫生组织的定义相当吻合。低级别星形细胞瘤的年龄别发病率相当稳定。高级别星形细胞瘤的发病率随年龄急剧上升，70岁后下降，而临床诊断肿瘤的发病率持续上升。这些肿瘤类型的男女比例相对较高（1.6 - 1.7）。我们得出结论，荷兰原发性中枢神经系统癌症的登记对于胶质瘤、胚胎性肿瘤和淋巴瘤而言可能几乎是完整且有效的。
