抗氧化剂和黏膜保护剂：炎症性肠病切实可行的治疗选择？
Antioxidants and mucosa protectives: realistic therapeutic options in inflammatory bowel disease?
作者信息
Kruidenier L, Verspaget H W
机构信息
Department of Gastroenterology and Hepatology, Leiden University Medical Center, The Netherlands.
出版信息
Mediators Inflamm. 1998;7(3):157-62. doi: 10.1080/09629359891081.
Abstract
Oxidative damage is involved in the pathogenic process of idiopathic chronic inflammatory bowel disease. Although specific intervention in the oxidative cascade showed promising results in animal models and preliminary patient trials, the clinical efficacy of antioxidants still has to be established. Mucosa protection, for example by dietary fatty acids, seems to attenuate the intestinal inflammatory process as well but awaits definite clinical proof for the treatment of inflammatory bowel disease.
摘要
氧化损伤参与特发性慢性炎症性肠病的发病过程。尽管对氧化级联反应进行特异性干预在动物模型和初步患者试验中显示出有前景的结果，但抗氧化剂的临床疗效仍有待确定。例如，通过膳食脂肪酸进行黏膜保护似乎也能减轻肠道炎症过程，但治疗炎症性肠病的明确临床证据仍有待证实。
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