人内皮细胞中E-选择素和P-选择素同源配体的组成型表达。
Constitutive expression of E- and P-selectin cognate ligands in human endothelial cells.
作者信息
Palma C, Bellarosa D, Nardelli F, Mannori G, Manzini S
机构信息
Menarini Ricerche S.p.A. Department of Pharmacology, Rome, Italy.
出版信息
Mediators Inflamm. 1998;7(3):211-5. doi: 10.1080/09629359891153.
On human endothelial cells from umbilical cord (HUVEC) are present, in addition to E- and P-selectins, their cognate ligands. Differently from selectins, the ligand expression is constitutive and not modulated by interleukin-1beta. Such ligands appear to be different from the ones present in promyelocytic cells in order to promote cell adhesion to immobilized selectins. The expression of selectin-ligands on HUVEC cells suggest that selectins can participate in endothelial signalling besides their role as adhesion molecules for circulating blood cells. However, despite their role in chemotaxis, selectins do not contribute to HUVEC tube formation in Matrigel.
除了E-选择素和P-选择素外，人脐静脉内皮细胞（HUVEC）上还存在它们的同源配体。与选择素不同，配体的表达是组成性的，不受白细胞介素-1β的调节。这些配体似乎与早幼粒细胞中的配体不同，以促进细胞与固定化选择素的粘附。HUVEC细胞上选择素配体的表达表明，选择素除了作为循环血细胞的粘附分子外，还可以参与内皮信号传导。然而，尽管选择素在趋化作用中发挥作用，但它们对基质胶中HUVEC管的形成没有贡献。
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