来自阿根廷的丙型肝炎病毒株的基因组和系统发育分析。
Genomic and phylogenetic analysis of hepatitis C virus strains from Argentina.
作者信息
Quarleri J F, Robertson B H, Mathet V, Sinha S D, Badía I, Frider B, Ferro A, Galoppo C, Sookoian S, Castaño G, Oubiã J R
机构信息
Departmento de Microbiologia, Parasitologia e Inmunologia, Facultad de Medicina, Universidad de Buenos Aires, Argentina.
出版信息
Medicina (B Aires). 1998;58(2):153-9.
HCV genomic characterization was performed by nucleotide sequence analysis (n=50) combined with restriction fragment length polymorphism (RFLP) of the 5' UTR region in 82 isolates corresponding to different Argentine groups. Genotype 1 was detected in 70.7% of the samples (58 out of 82), genotype 2 in 21.9% (18 of 82) and genotype 3 in the remaining 6 sera (7.3%). HCV 1b subtype contributed with 35.3% to the whole population studied (29 to 82) and was detected in 6 out of 21 sporadic cases. Besides their epidemiological significance, these results should be taken into account when future vaccines are considered on the basis of geographical HCV genotypic prevalence.
通过核苷酸序列分析（n = 50）并结合82株对应不同阿根廷人群的分离株5'非翻译区（UTR）的限制性片段长度多态性（RFLP），对丙型肝炎病毒（HCV）进行基因组特征分析。在70.7%的样本（82份中的58份）中检测到1型基因型，21.9%（82份中的18份）为2型基因型，其余6份血清（7.3%）为3型基因型。HCV 1b亚型在整个研究人群中占35.3%（82份中的29份），在21例散发病例中的6例中检测到。除了其流行病学意义外，在根据HCV基因型地理流行情况考虑未来疫苗时，应考虑这些结果。
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