Török T, Bari F, Paprika D, Rudas L, Kardos A, Gingl Z
Medical Intensive Care Unit, Albert Szent-Györgyi Medical University, Szeged, Hungary.
Acta Physiol Hung. 1997;85(2):153-62.
Laser Doppler flowmetry is a non-invasive tool in assessing the temporary changes of skin microcirculation. Another non-invasive equipment the Finapres 2300 finger blood pressure monitor provides a continuous blood pressure signal. The combination of the two devices allows short-term monitoring of the changes in the resistance of skin microvasculature. In order to assess the role of skin blood vessels in physiological responses to complex reflex tests Valsalva manoeuvre was performed by 12 healthy volunteers. For comparison a thermal stimulation (cold pressor) test was also done.
The two tests resulted in skin blood flow responses of similar magnitude. The changes in calculated regional peripheral resistance (dRPR) indicated that both responses involved active vasoconstrictor mechanisms. It is of importance that the active vasoconstriction could be documented only at the late strain phase (V2) but not in the early strain phase (V1) of the Valsalva manoeuvre (%dRPR in V1 = 0.14 vs. V2 = 0.96, p < 0.05).
In conclusion our findings support the theory that changes in the tone of the skin blood vessels parallel the changes in systemic vasculature in response to complex reflex tests. This is the first report which documents the feasibility of the continuous monitoring of the regional peripheral resistance.
激光多普勒血流仪是评估皮肤微循环短期变化的一种非侵入性工具。另一种非侵入性设备——Finapres 2300手指血压监测仪可提供连续的血压信号。这两种设备联合使用能够对皮肤微血管阻力的变化进行短期监测。为了评估皮肤血管在对复杂反射测试（瓦尔萨尔瓦动作）的生理反应中的作用，12名健康志愿者进行了瓦尔萨尔瓦动作。作为对照，还进行了热刺激（冷加压）测试。
两项测试引起的皮肤血流反应幅度相似。计算得出的局部外周阻力（dRPR）变化表明，两种反应均涉及主动血管收缩机制。重要的是，主动血管收缩仅在瓦尔萨尔瓦动作的晚期应变阶段（V2）出现，而在早期应变阶段（V1）未出现（V1阶段的%dRPR = 0.14，V2阶段为0.96，p < 0.05）。
总之，我们的研究结果支持以下理论：在对复杂反射测试的反应中，皮肤血管张力的变化与全身血管系统的变化平行。这是首篇记录局部外周阻力连续监测可行性的报告。
