血清阴性重症肌无力与人类免疫缺陷病毒感染：对静脉注射丙种球蛋白和泼尼松的反应
Seronegative myasthenia gravis and human immunodeficiency virus infection: response to intravenous gamma globulin and prednisone.
作者信息
Strong J, Zochodne D W
机构信息
Department of Clinical Neurosciences, University of Calgary, Alberta, Canada.
出版信息
Can J Neurol Sci. 1998 Aug;25(3):254-6. doi: 10.1017/s0317167100034119.
BACKGROUND
There are only rare reports of myasthenia gravis complicating human immunodeficiency virus infection. The role of immunomodulatory therapy is unknown.
METHODS
Case report and literature review.
RESULTS
The diagnosis of human immunodeficiency virus infection followed that of myasthenia gravis in a 35-year-old man. Clinical and electrophysiological features were diagnostic of generalized myasthenia gravis but two edrophonium chloride tests and acetylcholine receptor antibodies were negative. Prednisone therapy and intravenous gamma globulin were associated with rapid clinical recovery.
CONCLUSIONS
Prednisone therapy and intravenous gamma globulin may be helpful in patients with generalized myasthenia gravis complicating HIV infection.
背景
重症肌无力合并人类免疫缺陷病毒感染的报道极为罕见。免疫调节疗法的作用尚不清楚。
方法
病例报告及文献综述。
结果
一名35岁男性在诊断出重症肌无力后被诊断出感染了人类免疫缺陷病毒。临床和电生理特征诊断为全身型重症肌无力，但两次依酚氯铵试验及乙酰胆碱受体抗体均为阴性。泼尼松治疗和静脉注射丙种球蛋白使患者临床症状迅速恢复。
结论
泼尼松治疗和静脉注射丙种球蛋白可能有助于全身型重症肌无力合并HIV感染的患者。
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