Tejada F, Cremades A, Monserrat F, Peñafiel R
Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Murcia, Spain.
Clin Chim Acta. 1998 Jul 6;275(1):63-9. doi: 10.1016/s0009-8981(98)00077-1.
The antihormone RU486 (mifepristone, 11beta-(4-dimethylaminophenyl)-17beta-hydroxy-17alpha-(prop- 1-ynyl)-estra-4,9-dien-3-one) is currently used in many endocrinological studies and in clinical practice as a contraceptive agent. The results presented here indicate that the synthetic steroid RU486 may interfere in determinations of testosterone and estradiol when using some commercial kits. Although the cross reactivity is low (0.30% for testosterone and 0.16% for estradiol), in animal experiments RU486 doses higher than 5 mg/kg may produce false positive results in the estimation of plasma testosterone (specially in castrated male or female mice) or estradiol concentrations, even in samples obtained 48 h after the administration of this antihormone.
抗激素RU486（米非司酮，11β-（4-二甲基氨基苯基）-17β-羟基-17α-（丙-1-炔基）-雌-4,9-二烯-3-酮）目前在许多内分泌学研究和临床实践中用作避孕药。此处给出的结果表明，当使用某些商业试剂盒时，合成类固醇RU486可能会干扰睾酮和雌二醇的测定。尽管交叉反应性较低（睾酮为0.30%，雌二醇为0.16%），但在动物实验中，高于5mg/kg的RU486剂量可能会在血浆睾酮（特别是去势雄性或雌性小鼠）或雌二醇浓度的估计中产生假阳性结果，即使是在给予这种抗激素48小时后获得的样本中。
