Gaffey M J, Mills S E, Frierson H F, Askin F B, Maygarden S J
Department of Pathology, the University of Virginia Health Sciences Center, Charlottesville 22908, USA.
Am J Surg Pathol. 1998 Aug;22(8):1020-5. doi: 10.1097/00000478-199808000-00013.
A clear cell variant of primary pulmonary carcinoid tumor is described. The tumor arose in a 53-year-old woman who was incidentally found to have a solitary pulmonary nodule in the left upper lobe during routine chest roentgenography. Histologically, the tumor was composed of predominantly clear to lightly eosinophilic, polygonal cells with bland nuclei arranged in sheets and nests. Nuclear pleomorphism, necrosis, vascular invasion, and mitotic figures were not seen. The tumor cells were negative for oil-red-O and periodic acid-Schiff stains with and without diastase pretreatment on frozen and formalin-fixed sections, respectively. During immunohistochemical evaluation, the tumor cells were focally positive for cytokeratin and diffusely positive for neuron-specific enolase and chromogranin. Electron microscopy performed on paraffin block-retrieved tissue showed the presence of electron-dense, neurosecretory-type granules and variably sized vacuolated areas within the cytoplasm. the nature of which remained unclear. Intracytoplasmic glycogen or lipid were not identified. To our knowledge, this is the first report of pulmonary clear cell carcinoid tumor.
本文描述了原发性肺类癌肿瘤的一种透明细胞变体。该肿瘤发生于一名53岁女性，她在常规胸部X线检查时偶然发现左上叶有一个孤立性肺结节。组织学上，肿瘤主要由透明至轻度嗜酸性的多边形细胞组成，细胞核温和，呈片状和巢状排列。未见核异型性、坏死、血管侵犯和核分裂象。在冷冻切片和福尔马林固定切片上，肿瘤细胞分别经淀粉酶预处理和未经预处理的油红O染色及过碘酸希夫染色均为阴性。在免疫组化评估中，肿瘤细胞细胞角蛋白局灶阳性，神经元特异性烯醇化酶和嗜铬粒蛋白弥漫阳性。对石蜡块回收组织进行的电子显微镜检查显示，细胞质内存在电子致密的神经分泌型颗粒和大小不一的空泡化区域，其性质尚不清楚。未发现细胞质内糖原或脂质。据我们所知，这是肺透明细胞类癌肿瘤的首例报告。
