Baldwin D S, Birtwistle J
University Department of Psychiatry, Royal South Hants Hospital, Southampton, UK.
J Clin Psychiatry. 1998;59 Suppl 8:39-44; discussion 45-6.
This article reviews the incidences of side effects in placebo-controlled clinical trials of drug therapy in patients with panic disorder. We performed a MEDLINE search for placebo-controlled studies in panic disorder that reported the incidences of side effects, published in English language, peer-reviewed journals between 1992 and 1997. We discuss the side effects experienced by patients receiving tricyclic antidepressants, serotonin selective reuptake inhibitors, and benzodiazepines, the drug classes most commonly prescribed for the treatment of panic disorder. Available evidence suggests that, with respect to tolerability, serotonin selective reuptake inhibitors are the most favorable treatment choice for patients with panic disorder.
本文回顾了惊恐障碍患者药物治疗的安慰剂对照临床试验中的副作用发生率。我们在MEDLINE数据库中检索了1992年至1997年间发表在英文、同行评审期刊上的关于惊恐障碍安慰剂对照研究且报告了副作用发生率的文献。我们讨论了接受三环类抗抑郁药、5-羟色胺选择性再摄取抑制剂和苯二氮䓬类药物（治疗惊恐障碍最常用的几类药物）的患者所经历的副作用。现有证据表明，就耐受性而言，5-羟色胺选择性再摄取抑制剂是惊恐障碍患者最有利的治疗选择。
