De Braekeleer M, Allard C, Leblanc J P, Aubin G, Simard F
Cystic Fibrosis Research Laboratory, Université du Québec à Chicoutimi, Canada.
Eur J Clin Microbiol Infect Dis. 1998 Apr;17(4):269-71. doi: 10.1007/BF01699984.
The present study was aimed at analyzing whether the rate of colonization and the age at colonization with Pseudomonas aeruginosa was genetically determined in cystic fibrosis (CF) patients. These two variables were calculated among 127 CF patients whose genotypes were known and who were monitored at the Clinique de Fibrose Kystique in Saguenay Lac-Saint-Jean. No statistically significant differences were found in the rate or the age at colonization when the patients were grouped by genotype; however, this result could be due to the small number of patients in each genotype group. The rate of colonization was significantly lower among CF patients carrying the A455E mutation, a "mild" allele with respect to exocrine pancreatic function, than among those carrying either the deltaF508 or the 621 + IG- > T mutation, both of which are "severe" alleles. The results confirm previous reports that the rate of colonization with Pseudomonas aeruginosa is, at least in part, genetically determined.
本研究旨在分析囊性纤维化（CF）患者中铜绿假单胞菌的定植率和定植年龄是否由基因决定。在127名已知基因型且在萨格奈-圣让湖地区囊性纤维化诊所接受监测的CF患者中计算了这两个变量。当按基因型对患者进行分组时，在定植率或定植年龄方面未发现统计学上的显著差异；然而，这一结果可能是由于每个基因型组中的患者数量较少。携带A455E突变（一种在外分泌胰腺功能方面为“轻度”的等位基因）的CF患者的定植率显著低于携带ΔF508或621 + IG>T突变（这两种均为“重度”等位基因）的患者。结果证实了先前的报道，即铜绿假单胞菌的定植率至少部分由基因决定。
