小鼠视交叉上核和终板血管器中一个不依赖光的振荡基因mPer3 。
A light-independent oscillatory gene mPer3 in mouse SCN and OVLT.
作者信息
Takumi T, Taguchi K, Miyake S, Sakakida Y, Takashima N, Matsubara C, Maebayashi Y, Okumura K, Takekida S, Yamamoto S, Yagita K, Yan L, Young M W, Okamura H
机构信息
Department of Anatomy and Brain Science, Kobe University School of Medicine, Chuo-ku, Kobe 650-0017, Japan.
出版信息
EMBO J. 1998 Aug 17;17(16):4753-9. doi: 10.1093/emboj/17.16.4753.
Abstract
A new member of the mammalian period gene family, mPer3, was isolated and its expression pattern characterized in the mouse brain. Like mPer1, mPer2 and Drosophila period, mPer3 has a dimerization PAS domain and a cytoplasmic localization domain. mPer3 transcripts showed a clear circadian rhythm in the suprachiasmatic nucleus (SCN). Expression of mPer3 was not induced by exposure to light at any phase of the clock, distinguishing this gene from mPer1 and mPer2. Cycling expression of mPer3 was also found outside the SCN in the organum vasculosum lamina terminalis (OVLT), a potentially key region regulating rhythmic gonadotropin production and pyrogen-induced febrile phenomena. Thus, mPer3 may contribute to pacemaker functions both inside and outside the SCN.
摘要
哺乳动物周期基因家族的一个新成员mPer3被分离出来，并对其在小鼠大脑中的表达模式进行了表征。与mPer1、mPer2和果蝇周期基因一样，mPer3具有一个二聚化PAS结构域和一个细胞质定位结构域。mPer3转录本在视交叉上核（SCN）中呈现出明显的昼夜节律。在生物钟的任何阶段，暴露于光照都不会诱导mPer3的表达，这使该基因与mPer1和mPer2有所区别。在终板血管器（OVLT）中也发现了mPer3的周期性表达，OVLT是调节节律性促性腺激素产生和热原诱导发热现象的一个潜在关键区域。因此，mPer3可能对SCN内外的起搏器功能都有贡献。
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