Edstrom H, Choslovsky S, Cherniack R M
Am Rev Respir Dis. 1976 Oct;114(4):761-6. doi: 10.1164/arrd.1976.114.4.761.
The ventilatory response to CO2 during resistive loading was determined in normal subjects when the end-expiratory level was allowed to increase and when it was restored to that present in the unloaded state. Restoration of the end-expiratory level of that seen in the unloaded state, during the resistive loading, resulted in an increase in ventilatory response to CO2. The mechanism by which increases in lung volume affect the ventilatory response to CO2 is unknown; multiple factors are likely to be involved. It is suggested that an increase in end-expiratory level plays a major role in limiting the ventilatory response to CO2 during resistive loading and may also be an important factor in the reduced ventilatory response to CO2 that is seen clinically when there is obstruction to air flow.
在正常受试者中，当呼气末水平被允许升高以及恢复到无负荷状态时的水平时，测定了阻力负荷期间对二氧化碳的通气反应。在阻力负荷期间，将呼气末水平恢复到无负荷状态时的水平，会导致对二氧化碳的通气反应增加。肺容积增加影响对二氧化碳通气反应的机制尚不清楚；可能涉及多种因素。有人提出，呼气末水平的升高在限制阻力负荷期间对二氧化碳的通气反应中起主要作用，并且可能也是临床上当气流受阻时对二氧化碳通气反应降低的一个重要因素。
