在活跃的中枢网络中，突触信号传导仅适度改变被动膜特性。
Synaptic signaling in an active central network only moderately changes passive membrane properties.
作者信息
Raastad M, Enríquez-Denton M, Kiehn O
机构信息
Section of Neurophysiology, Department of Physiology, The Panum Institute, Blegdamsvej 3, 2200 Copenhagen N, Denmark.
出版信息
Proc Natl Acad Sci U S A. 1998 Aug 18;95(17):10251-6. doi: 10.1073/pnas.95.17.10251.
Abstract
The membrane resistance of mammalian central neurons may be dramatically reduced by synaptic events during network activity, thereby changing their integration properties. We have used the isolated neonatal rat spinal cord to provide measurements of the effect of synaptic signaling on passive membrane properties during network activity. Synaptic signaling could take place during fictive locomotor activity with only modest (on average 35%) reduction of the input resistance (Rin) and of the cell's charging time constant (tauin). Individual synaptic signals, however, often introduced a peak conductance that was greater than the input conductance (Gin = 1/Rin) without synaptic activity. The combination of moderate average synaptic conductance and large conductance of individual synaptic signals suggests that individual presynaptic neurons have large but short-lasting influence on the integration properties of postsynaptic neurons.
摘要
在网络活动期间，哺乳动物中枢神经元的膜电阻可能会因突触事件而显著降低，从而改变其整合特性。我们利用新生大鼠离体脊髓来测量网络活动期间突触信号对被动膜特性的影响。在虚拟运动活动期间可能会发生突触信号传递，此时输入电阻（Rin）和细胞充电时间常数（tauin）仅适度降低（平均35%）。然而，单个突触信号常常会引入一个峰值电导，该电导大于无突触活动时的输入电导（Gin = 1/Rin）。适度的平均突触电导与单个突触信号的大电导相结合，表明单个突触前神经元对突触后神经元的整合特性具有较大但持续时间短的影响。
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