Tronchet J M, Kovács I, Barbalat-Rey F, Holm M V
Department of Pharmaceutical Chemistry, Sciences II, University of Geneva, Switzerland.
Nucleosides Nucleotides. 1998 Jun;17(6):1115-23. doi: 10.1080/07328319808004224.
Reaction of 2',5'-di-O-TBDMS-3'-ketouridine 1 with L-cysteine yielded in good yield a resolvable mixture of the two expected epimeric spironucleosides 2 and 3. Amidification of their carboxylic group took place readily and the ribo carboxamide 4 was oxidized to the corresponding sulfoxide 6. Despite their similarity to TSAO derivatives these compounds did not exhibit usable anti-HIV activity.
