Daelemans D, Vandamme A M, Shuto S, Matsuda A, De Clercq E
Rega Institute for Medical Research, Katholieke Universiteit Leuven, Belgium.
Nucleosides Nucleotides. 1998 Jan-Mar;17(1-3):479-86. doi: 10.1080/07328319808005192.
The R- and S-isomers of 6'-C-neplanocin A analogues, which are all known as inhibitors of S-adenosylhomocysteine (AdoHcy) hydrolase, were studied for their inhibitory effects on Human Immunodeficiency Virus type 1 (HIV-1) replication and HIV-1 Tat-mediated transactivation. The R-isomers showed much greater activity against AdoHcy hydrolase than the S-isomers. The same differential activity was observed against the HIV-1 replication and the Tat transactivation.
6'-C-奈拉滨类似物的R-和S-异构体均为已知的S-腺苷同型半胱氨酸（AdoHcy）水解酶抑制剂，研究了它们对1型人类免疫缺陷病毒（HIV-1）复制及HIV-1反式激活因子（Tat）介导的反式激活作用的抑制效果。R-异构体对AdoHcy水解酶的活性比S-异构体强得多。在HIV-1复制及Tat反式激活方面也观察到了同样的差异活性。
