Furrer H, Wendland T, Minder C, Christen A, von Overbeck J, Grunow R, Pichler W, Malinverni R P
AIDS Unit, Medical Policlinic, University of Berne, Switzerland.
AIDS. 1998 Jul 30;12(11):1341-6. doi: 10.1097/00002030-199811000-00016.
To study whether syncytium-inducing (SI)/non-SI (NSI) phenotype of HIV-1 is associated with CD4+ lymphocyte count, plasma HIV RNA level, clinical stage and sociodemographic characteristics in antiretroviral-naive HIV-1-infected patients.
Cross-sectional analysis of single centre cohort study data.
SI/NSI phenotype was determined using a cocultivation assay using patients' peripheral blood mononuclear cells and MT2 cells. Standard procedures were used for CD4+ cell counts and viral load measurements in plasma. Univariate and multivariate analyses of association of CD4+ cell counts, viral load, clinical stage, age, sex and mode of HIV transmission were performed.
In univariate analysis, SI phenotype was significantly associated with lower CD4+ cell counts, higher HIV RNA plasma levels, symptomatic HIV disease, male sex and age 32-36 years (middle tercile). In multivariate analysis, only lower CD4+ cell counts were associated with SI phenotype (odds ratio per increase of 100 x 10(6)/l, 0.54; 95% confidence interval, 0.38-0.78).
HIV-1 SI phenotype was associated with lower CD4+ cell counts but not with higher plasma viral load, clinical stage or sociodemographic variables.
研究在未接受抗逆转录病毒治疗的HIV-1感染患者中，HIV-1的合胞体诱导（SI）/非合胞体诱导（NSI）表型是否与CD4+淋巴细胞计数、血浆HIV RNA水平、临床分期及社会人口学特征相关。
对单中心队列研究数据进行横断面分析。
采用患者外周血单个核细胞与MT2细胞共培养试验确定SI/NSI表型。采用标准程序检测血浆中的CD4+细胞计数和病毒载量。对CD4+细胞计数、病毒载量、临床分期、年龄、性别及HIV传播方式之间的关联性进行单因素和多因素分析。
在单因素分析中，SI表型与较低的CD4+细胞计数、较高的血浆HIV RNA水平、有症状的HIV疾病、男性性别及32 - 36岁（三分位数区间的中间部分）显著相关。在多因素分析中，仅较低的CD4+细胞计数与SI表型相关（每增加100×10⁶/L的比值比为0.54；95%置信区间为0.38 - 0.78）。
HIV-1的SI表型与较低的CD4+细胞计数相关，但与较高的血浆病毒载量、临床分期或社会人口学变量无关。
