Kao C H, Ho Y J, Lan J L, ChangLai S P, Chieng P U
Department of Nuclear Medicine, Taichung Veterans General Hospital, Republic of China.
J Nucl Med. 1998 Aug;39(8):1354-6.
Involvement of the brain is one of the most important complications of Sjögren's syndrome (SS). However, diagnosis of brain involvement in SS patients is difficult due to the lack of effective imaging methods. In this study, we compared two updated brain imaging modalities, 18F-2-fluoro-2-deoxy-D-glucose (FDG) PET and 99mTc-hexamethyl propyleneamine oxime (HMPAO) SPECT, in SS patients with neuropsychiatric manifestations, to detect glucose metabolism of the brain and regional cerebral blood flow.
Sixteen primary female SS patients with normal brain MRI findings were enrolled in this study.
Technetium-99m-HMPAO SPECT findings were abnormal in 13 (81%) patients. Parietal and temporal lobes were the most common areas of brain involvement. Fluorine-18-FDG PET findings were abnormal in 3 (19%) patients. Temporal lobes were the most common areas of brain involvement.
We conclude that brain HMPAO SPECT has better correlation with clinical manifestations than brain FDG PET or CT/MRI.
脑部受累是干燥综合征（SS）最重要的并发症之一。然而，由于缺乏有效的成像方法，SS患者脑部受累的诊断较为困难。在本研究中，我们比较了两种更新的脑成像方式，即18F - 2 - 氟 - 2 - 脱氧 - D - 葡萄糖（FDG）PET和99mTc - 六甲基丙烯胺肟（HMPAO）SPECT，用于检测有神经精神症状的SS患者的脑葡萄糖代谢和局部脑血流。
本研究纳入了16例脑部MRI检查结果正常的原发性女性SS患者。
13例（81%）患者的99mTc - HMPAO SPECT检查结果异常。顶叶和颞叶是最常受累的脑区。3例（19%）患者的18F - FDG PET检查结果异常。颞叶是最常受累的脑区。
我们得出结论，与脑FDG PET或CT/MRI相比，脑HMPAO SPECT与临床表现的相关性更好。
