Kao C H, Lan J L, ChangLai S P, Chieng P U
Department of Nuclear Medicine, Taichung Veterans General Hospital, Taiwan, Republic of China.
J Nucl Med. 1998 Oct;39(10):1707-10.
Involvement of the brain is one of the most important complications of Behçet's disease (BS). It is difficult to diagnose, however, because of the lack of effective imaging methods.
Thirteen BS patients with neuropsychiatric symptoms or signs [Neuro-Behçet's syndrome (NBS)] were included in this study. We combined two routine brain imaging modalities-brain SPECT with 99mTc-hexamethyl propyleneamine oxime (HMPAO) and brain MRI-with clinical manifestations to diagnose brain involvement.
Technetium-99m-HMPAO brain SPECT findings were abnormal in 100% (13/13) of patients. Brain MRI findings were abnormal in 31% (4/13) of patients. Gray matter was involved more commonly than white matter. In the gray matter, the cerebral cortex was the most commonly involved area and the cerebellum was the least commonly involved area in NBS.
SPECT is a more sensitive and useful tool in detecting brain involvement in NBS patients compared with brain MRI. The combination of HMPAO and MRI is necessary to detect brain lesions in both gray and white matter in NBS.
脑部受累是白塞病（BS）最重要的并发症之一。然而，由于缺乏有效的影像学方法，其诊断较为困难。
本研究纳入了13例有神经精神症状或体征的白塞病患者[神经白塞综合征（NBS）]。我们将两种常规脑部成像方式——99mTc-六甲基丙烯胺肟（HMPAO）脑单光子发射计算机断层扫描（SPECT）和脑磁共振成像（MRI）——与临床表现相结合来诊断脑部受累情况。
99mTc-HMPAO脑SPECT检查结果显示100%（13/13）的患者异常。脑MRI检查结果显示31%（4/13）的患者异常。灰质比白质更常受累。在灰质中，大脑皮质是NBS中最常受累的区域，而小脑是最不常受累的区域。
与脑MRI相比，SPECT在检测NBS患者脑部受累方面是一种更敏感且有用的工具。HMPAO和MRI联合使用对于检测NBS患者灰质和白质中的脑病变是必要的。
