Takeuchi R, Yonekura Y, Matsuda H, Nishimura Y, Tanaka H, Ohta H, Sakahara H, Konishi J
Department of Internal Medicine, Nishi-Kobe Medical Center, Kobe, Japan.
J Nucl Med. 1998 Aug;39(8):1360-2.
Regional resting cerebral blood flow and vascular reserve in a patient with transient global amnesia (TGA) were evaluated during and after a TGA episode using 99mTc-ethyl cysteinate dimer (ECD). The patient had consecutive SPECT studies before and after acetazolamide (ACZ) administration with adjunctive radionuclide angiography using equal-volume-split 99mTc-ECD. SPECT study during TGA episode showed poor vasodilatory reactivity to ACZ in the left medial temporal region involving the hippocampus and resting hypoperfusion in the regions bilaterally. The resting hypoperfusion with reserved vasodilatory reactivity to ACZ also was seen in the bilateral thalami. Abnormal findings in these regions disappeared on the follow-up SPECT study 15 days after the onset. No previous SPECT evaluation of regional abnormalities of both hemodynamic reserve and resting perfusion during and after an episode of TGA has been reported.
在短暂性全面性遗忘症（TGA）发作期间及发作后，使用99mTc - 半胱氨酸乙酯二聚体（ECD）对一名TGA患者的局部静息脑血流量和血管储备进行了评估。该患者在服用乙酰唑胺（ACZ）前后连续进行了单光子发射计算机断层扫描（SPECT）研究，并使用等体积分割的99mTc - ECD进行辅助放射性核素血管造影。TGA发作期间的SPECT研究显示，左侧内侧颞叶区域（包括海马体）对ACZ的血管舒张反应性较差，且双侧区域存在静息灌注不足。双侧丘脑也可见静息灌注不足，但对ACZ具有保留的血管舒张反应性。这些区域的异常发现在发病后15天的随访SPECT研究中消失。此前尚未有关于TGA发作期间及发作后血流动力学储备和静息灌注区域异常的SPECT评估报告。
