Takeuchi Ryo, Matsuda Hiroshi, Yoshioka Katsunori, Yonekura Yoshiharu
Division of Nuclear Medicine, Nishi-Kobe Medical Center, Kohjidai 5-7-1, 651-2273, Nishi-ku, Kobe-City, Hyogo, Japan.
Eur J Nucl Med Mol Imaging. 2004 Apr;31(4):578-89. doi: 10.1007/s00259-003-1406-8. Epub 2004 Jan 14.
The aim of this study was to determine the areas involved in episodes of transient global amnesia (TGA) by calculation of cerebral blood flow (CBF) using 3DSRT, fully automated ROI analysis software which we recently developed. Technetium-99m L, L-ethyl cysteinate dimer single-photon emission tomography ((99m)Tc-ECD SPET) was performed during and after TGA attacks on eight patients (four men and four women; mean study interval, 34 days). The SPET images were anatomically standardized using SPM99 followed by quantification of 318 constant ROIs, grouped into 12 segments (callosomarginal, precentral, central, parietal, angular, temporal, posterior cerebral, pericallosal, lenticular nucleus, thalamus, hippocampus and cerebellum), in each hemisphere to calculate segmental CBF (sCBF) as the area-weighted mean value for each of the respective 12 segments based on the regional CBF in each ROI. Correlation of the intra- and post-episodic sCBF of each of the 12 segments of the eight patients was estimated by scatter-plot graphical analysis and Pearson's correlation test with Fisher's Z-transformation. For the control, (99m)Tc-ECD SPET was performed on eight subjects (three men and five women) and repeated within 1 month; the correlation between the first and second sCBF values of each of the 12 segments was evaluated in the same way as for patients with TGA. Excellent reproducibility between the two sCBF values was found in all 12 segments of the control subjects. However, a significant correlation between intra- and post-episodic sCBF was not shown in the thalamus or angular segments of TGA patients. The present study was preliminary, but at least suggested that thalamus and angular regions are closely involved in the symptoms of TGA.
本研究的目的是通过使用我们最近开发的全自动ROI分析软件3DSRT计算脑血流量（CBF），来确定短暂性全面性遗忘症（TGA）发作所涉及的区域。在8名患者（4名男性和4名女性；平均研究间隔为34天）的TGA发作期间及之后进行了锝-99m L，L-乙基半胱氨酸二聚体单光子发射断层扫描（（99m）Tc-ECD SPET）。使用SPM99对SPET图像进行解剖学标准化，随后对每个半球中的318个恒定ROI进行量化，这些ROI被分为12个节段（胼胝体缘支、中央前回、中央回、顶叶、角回、颞叶、大脑后动脉、胼胝周动脉、豆状核、丘脑、海马和小脑），以计算节段性CBF（sCBF），即基于每个ROI中的区域CBF，对12个相应节段各自的面积加权平均值。通过散点图图形分析和带有Fisher Z变换的Pearson相关检验，估计8名患者12个节段中每个节段发作期内和发作后的sCBF之间的相关性。作为对照，对8名受试者（3名男性和5名女性）进行了（99m）Tc-ECD SPET检查，并在1个月内重复进行；以与TGA患者相同的方式评估12个节段中每个节段的第一个和第二个sCBF值之间的相关性。在对照受试者的所有12个节段中，发现两个sCBF值之间具有出色的可重复性。然而，TGA患者的丘脑或角回节段在发作期内和发作后的sCBF之间未显示出显著相关性。本研究是初步的，但至少表明丘脑和角回区域与TGA的症状密切相关。
