泪液中的放射性碘分泌。
Radioiodine secretion in tears.
作者信息
Bakheet S M, Hammami M M, Hemidan A, Powe J E, Bajaafar F
机构信息
Department of Radiology, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia.
出版信息
J Nucl Med. 1998 Aug;39(8):1452-4.
UNLABELLED
Lacrimal secretion of radioiodine has been suspected from previous scintigraphic observations. We semiquantitated radioiodine secretion in the tears of a thyroid-ablated patient with an artificial eye while the patient was on thyroxine treatment.
METHODS
After an oral dose of 555 MBq (15 mCi) 123I, 12 tear samples were collected over 24 hr by using Schirmer papers. Radioactivity in each sample was determined in a well counter 27 hr after radioiodine ingestion and was corrected for decay and counting efficiency.
RESULTS
Radioactivity was detectable at 15 min and at up to 24 hr after radioiodine ingestion and peaked at around 60 min (215 Bq/microl or 39 x 10(6)% of the administered dose/microl. Considering a tear-flow rate of 1 microl/min, the total radioactivity secreted in the first 4 hr was estimated to be 56 kBq, representing about 0.01% of the administered dose.
CONCLUSION
An appreciable amount of ingested radioiodine could be secreted in tears. The potential damage of the lacrimal gland after high doses of 131I treatment deserves further study.
未标记
根据以往的闪烁扫描观察结果，怀疑泪液中有放射性碘分泌。我们对一名甲状腺切除且佩戴义眼的患者在接受甲状腺素治疗期间泪液中的放射性碘分泌进行了半定量分析。
方法
口服555 MBq（15 mCi）的123I后，使用泪液试纸在24小时内收集12份泪液样本。在摄入放射性碘27小时后，在井型计数器中测定每个样本的放射性，并对衰变和计数效率进行校正。
结果
摄入放射性碘后15分钟及直至24小时均可检测到放射性，在大约60分钟时达到峰值（215 Bq/μl或占给药剂量的39×10⁶%/μl）。考虑到泪液流速为1 μl/分钟，估计前4小时分泌的总放射性为56 kBq，约占给药剂量的0.01%。
结论
摄入的放射性碘有相当一部分可分泌到泪液中。大剂量131I治疗后泪腺的潜在损伤值得进一步研究。
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