Lindsey W H, Franz D A, Toung J S, London S D, Ogle R O
Department of Otolaryngology-Head and Neck Surgery, University of Virginia Medical Center, Charlottesville, USA.
Arch Otolaryngol Head Neck Surg. 1998 Aug;124(8):912-5. doi: 10.1001/archotol.124.8.912.
To create a standardized nonhealing defect of craniofacial, minimal load-bearing, endochondral type bone with geometric properties that are amenable to quantitative and biomechanical testing that can be used to develop new osteoconductive and osteoinductive engineering repair techniques.
Before-and-after randomized trial of an anatomical description.
Twenty-four retired male breeder Sprague-Dawley rats.
A standardized osseous defect was created by removing the nasal bones with a cutting burr to the level of the nasal mucosal membranes. The defects were not repaired, and groups of 8 animals were examined using planimetry, computed tomographic scanning, and histological analysis at 1, 3, and 6 months following surgery to quantify defect repair.
Mean repair rate by surface area measurements at 1, 3, and 6 months was 5.75%, 4.89%, and 7.09%, respectively. Results from histological analysis revealed that the defects were filled with fibrous tissue. Computed tomographic scans showed the bone defect without repair.
This nasal osseous defect fulfills criteria to be considered as a critical-size defect that can be used to investigate new techniques for bone reconstruction.
创建一种标准化的颅面部非愈合性缺损，该缺损为软骨内成骨类型，承重极小，具有适合进行定量和生物力学测试的几何特性，可用于开发新的骨传导和骨诱导工程修复技术。
一项关于解剖学描述的前后随机试验。
24只退役雄性繁殖用斯普拉格-道利大鼠。
用切割钻将鼻骨切除至鼻粘膜水平，制造标准化骨缺损。缺损不予修复，术后1、3和6个月时，对每组8只动物进行平面测量、计算机断层扫描和组织学分析，以量化缺损修复情况。
1、3和6个月时，通过表面积测量得出的平均修复率分别为5.75%、4.89%和7.09%。组织学分析结果显示缺损处充满纤维组织。计算机断层扫描显示骨缺损未修复。
这种鼻骨缺损符合被视为临界尺寸缺损的标准，可用于研究骨重建新技术。
