Lowy D R, Schiller J T
Laboratory of Cellular Oncology, National Cancer Institute, Bethesda, MD, USA.
J Natl Cancer Inst Monogr. 1998(23):27-30. doi: 10.1093/oxfordjournals.jncimonographs.a024169.
A subset of human papillomaviruses (HPVs) has been implicated as the principal etiologic agents of cervical cancer. Cervical cancers consistently retain and express two of the viral genes, E6 and E7. Although infection with HPV seems to be necessary, other factors, such as cellular immune function, play an important role in determining whether cervical infection will regress, persist, or progress to cancer. The close relationship between viral infection and cancer makes HPV an attractive target for prophylactic and therapeutic vaccines. Candidate vaccines have been shown to have efficacy in animal models, and human clinical trials are planned or in progress.
一部分人乳头瘤病毒（HPV）被认为是宫颈癌的主要病因。宫颈癌始终保留并表达两种病毒基因，即E6和E7。虽然HPV感染似乎是必要条件，但其他因素，如细胞免疫功能，在决定宫颈感染是否会消退、持续或发展为癌症方面起着重要作用。病毒感染与癌症之间的密切关系使HPV成为预防性和治疗性疫苗的一个有吸引力的靶点。候选疫苗已在动物模型中显示出疗效，并且正在计划或进行人体临床试验。
