Ravelli A, Viola S, Ramenghi B, Beluffi G, Zonta L A, Martini A
Clinica Pediatrica dell'Università di Pavia, Italy.
J Pediatr. 1998 Aug;133(2):262-5. doi: 10.1016/s0022-3476(98)70231-8.
We investigated the rate of radiologic progression, as measured by carpal length, in 26 children with juvenile chronic arthritis who were treated with methotrexate. After 2 years of treatment, the carpal length was significantly more deteriorated in nonresponders in both the "better" wrist (P = .001) and the "worse" wrist (P = .005). These results show that methotrexate may have a "disease modifying" potential in juvenile chronic arthritis.
