Fournier P E, Roux V, Caumes E, Donzel M, Raoult D
Unité des Rickettsies, CNRS, UPRESA 6020, Faculté de Médecine, Université de la Méditerranée, Marseille, France.
Clin Infect Dis. 1998 Aug;27(2):316-23. doi: 10.1086/514664.
African tick-bite fever, caused by Rickettsia africae and transmitted by Amblyomma ticks, is an emerging rickettsiosis in southern Africa. Because of increased tourism to this area, several cases in tourists have been reported recently. We report 13 cases of R. africae infection diagnosed in France that occurred in competitors returning from an adventure race in South Africa and compare our data with previously reported findings. Most of our patients presented with fever, headache, multiple inoculation eschars, and regional lymphadenopathies, but only 15.4% had a cutaneous rash. Diagnosis was confirmed either by isolation of R. africae from an eschar biopsy specimen or by serological methods, including cross-adsorption between R. africae and Rickettsia conorii. The purpose of this study was to raise physicians' awareness of R. africae infections in an attempt to facilitate the rapid diagnosis and treatment of imported African tick-bite fever in developed countries.
非洲蜱咬热由非洲立克次体引起，通过钝缘蜱传播，是南非一种新出现的立克次体病。由于该地区旅游业的增加，最近报告了几例游客感染病例。我们报告了在法国诊断出的13例非洲立克次体感染病例，这些病例发生在从南非一场冒险比赛归来的参赛者身上，并将我们的数据与先前报告的结果进行了比较。我们的大多数患者表现为发热、头痛、多处接种性焦痂和局部淋巴结病，但只有15.4%的患者有皮疹。通过从焦痂活检标本中分离出非洲立克次体或通过血清学方法（包括非洲立克次体与康氏立克次体之间的交叉吸附）确诊。本研究的目的是提高医生对非洲立克次体感染的认识，以便在发达国家促进对输入性非洲蜱咬热的快速诊断和治疗。
