Frieboes R M, Murck H, Stalla G K, Antonijevic I A, Steiger A
Max Planck Institute of Psychiatry, Department of Psychiatry, Munich, Germany.
J Clin Endocrinol Metab. 1998 Aug;83(8):2706-10. doi: 10.1210/jcem.83.8.5016.
Bidirectional interactions between nocturnal hormone secretion and sleep regulation are well established. In particular, a link between PRL and rapid eye movement (REM) sleep has been hypothesized. Short-term administration of PRL and even long-term hyperprolactinemia in animals increases REM sleep. Furthermore, sleep disorders are frequent symptoms in patients with endocrine diseases. We compared the sleep electroencephalogram of seven drug-free patients with prolactinoma (mean PRL levels 1450 +/- 1810 ng/mL; range between 146 and 5106 ng/mL) with that of matched controls. The patients had secondary hypogonadism but no other endocrine abnormalities. They spent more time in slow wave sleep than the controls (79.4 +/- 54.4 min in patients vs. 36.6 +/- 23.5 min in controls, P < 0.05). REM sleep variables did not differ between the samples. Our data suggest that chronic excessive enhancement of PRL levels exerts influences on the sleep electroencephalogram in humans. Our result, which seems to be in contrast to the enhanced REM sleep under hyperprolactinemia in rats, leads to the hypothesis that both slow wave sleep and REM sleep can be stimulated by PRL. These findings are in accordance with reports of good sleep quality in patients with prolactinoma, which is in contrast to that of patients with other endocrine diseases.
夜间激素分泌与睡眠调节之间的双向相互作用已得到充分证实。特别是，有人提出催乳素（PRL）与快速眼动（REM）睡眠之间存在联系。在动物中短期给予PRL甚至长期的高催乳素血症会增加REM睡眠。此外，睡眠障碍是内分泌疾病患者的常见症状。我们将7例无药物治疗的催乳素瘤患者（平均PRL水平为1450±1810 ng/mL；范围在146至5106 ng/mL之间）的睡眠脑电图与匹配的对照组进行了比较。这些患者患有继发性性腺功能减退，但无其他内分泌异常。他们在慢波睡眠中花费的时间比对照组多（患者为79.4±54.4分钟，对照组为36.6±23.5分钟，P<0.05）。样本之间的REM睡眠变量没有差异。我们的数据表明，PRL水平的慢性过度升高会对人类的睡眠脑电图产生影响。我们的结果似乎与大鼠高催乳素血症时REM睡眠增强相反，这导致了一种假设，即慢波睡眠和REM睡眠都可以被PRL刺激。这些发现与催乳素瘤患者睡眠质量良好的报道一致，这与其他内分泌疾病患者的情况相反。
