Bellgowan P S, Binder J R, Swanson S J, Hammeke T A, Springer J A, Frost J A, Mueller W M, Morris G L
Department of Neurology, Medical College of Wisconsin, Milwaukee 53226, USA.
Neurology. 1998 Aug;51(2):479-84. doi: 10.1212/wnl.51.2.479.
Functional MRI (FMRI) was used to investigate the effect of medial temporal lobe (MTL) pathology on activation of language encoding areas in patients with temporal lobe epilepsy (TLE).
Whole-brain FMRI was obtained. Twenty-eight patients with either left TLE (LTLE) or right TLE (RTLE) performed a semantic decision task alternating with an auditory perceptual task.
Activation of language areas in the frontal and parietal lobes was similar in both groups, with no group differences in the total number of active voxels. However, the RTLE group showed much stronger activation of the left MTL, including the hippocampus, parahippocampal gyrus, and collateral sulcus, than did the LTLE group.
Activation of the left MTL during semantic encoding discriminates patients with RTLE and LTLE. This FMRI technique may potentially be of use in determining memory lateralization and for predicting the side of seizure focus in TLE.
采用功能磁共振成像（FMRI）研究颞叶癫痫（TLE）患者内侧颞叶（MTL）病变对语言编码区域激活的影响。
进行全脑FMRI检查。28例左侧颞叶癫痫（LTLE）或右侧颞叶癫痫（RTLE）患者执行语义判断任务，并与听觉感知任务交替进行。
两组额叶和顶叶语言区域的激活情况相似，激活体素总数无组间差异。然而，RTLE组左侧MTL（包括海马体、海马旁回和侧副沟）的激活明显强于LTLE组。
语义编码期间左侧MTL的激活可区分RTLE和LTLE患者。这种FMRI技术可能有助于确定记忆的偏侧化，并预测TLE患者癫痫病灶的侧别。
