School of Psychology, Bangor University, Bangor LL57 2AS, United Kingdom.
Department of Neurosciences, King Faisal Specialist Hospital and Research Centre, Riyadh 11211, Saudi Arabia.
eNeuro. 2022 Mar 8;9(2). doi: 10.1523/ENEURO.0278-21.2022. Print 2022 Mar-Apr.
Disorders of the medial temporal lobe (MTL) adversely affect visual working memory (vWM) performance, including feature binding. It is unclear whether these impairments generalize across visual dimensions or are specifically spatial. To address this issue, we compared performance in two tasks of 13 epilepsy patients, who had undergone a temporal lobectomy, and 15 healthy controls. In the vWM task, participants recalled the color of one of two polygons, previously displayed side by side. At recall, a location or shape probe identified the target. In the perceptual task, participants estimated the centroid of three visible disks. Patients recalled the target color less accurately than healthy controls because they frequently swapped the nontarget with the target color. Moreover, healthy controls and right temporal lobectomy patients made more swap errors following shape than space probes. Left temporal lobectomy patients, showed the opposite pattern of errors instead. Patients and controls performed similarly in the perceptual task. We conclude that left MTL damage impairs spatial binding in vWM, and that this impairment does not reflect a perceptual or attentional deficit.
内侧颞叶（MTL）障碍会对视觉工作记忆（vWM）表现产生不利影响，包括特征绑定。这些损伤是否普遍存在于视觉维度，或者是特定于空间的，尚不清楚。为了解决这个问题，我们比较了 13 名接受颞叶切除术的癫痫患者和 15 名健康对照者在两项任务中的表现。在 vWM 任务中，参与者回忆之前并排显示的两个多边形中的一个颜色。在回忆时，位置或形状探针确定目标。在知觉任务中，参与者估计三个可见磁盘的质心。患者比健康对照组更不准确地回忆目标颜色，因为他们经常将非目标与目标颜色交换。此外，健康对照组和右颞叶切除术患者在形状探针后比空间探针做出更多的交换错误。左颞叶切除术患者则表现出相反的错误模式。患者和对照组在知觉任务中的表现相似。我们得出结论，左 MTL 损伤会损害 vWM 中的空间绑定，并且这种损伤不反映感知或注意力缺陷。
