托吡酯可增加健康人的大脑γ-氨基丁酸（GABA）水平。

Topiramate increases cerebral GABA in healthy humans.

作者信息

Kuzniecky R, Hetherington H, Ho S, Pan J, Martin R, Gilliam F, Hugg J, Faught E

机构信息

UAB Epilepsy Center, Department of Neurology, University of Alabama, Birmingham, USA.

出版信息

Neurology. 1998 Aug;51(2):627-9. doi: 10.1212/wnl.51.2.627.

DOI:10.1212/wnl.51.2.627

PMID:9710056

Abstract

Topiramate (TOP) is a novel anticonvulsant drug with multiple mechanisms of action used in the treatment of epilepsy. Measurements of cerebral GABA were obtained in six controls using 1H MRS at baseline and at 3 and 6 hours following the administration of 3 mg/kg of TOP. Brain GABA concentrations rose by 72% at 3 hours and by 64% at 6 hours compared with baseline (p < 0.004). This study demonstrates that TOP significantly increases human cerebral GABA concentrations in healthy individuals.

摘要

托吡酯（TOP）是一种新型抗惊厥药物，具有多种作用机制，用于治疗癫痫。在6名对照者中，于基线时以及给予3mg/kg托吡酯后3小时和6小时，使用1H磁共振波谱法测量脑内γ-氨基丁酸（GABA）。与基线相比，脑内GABA浓度在3小时时升高了72%，在6小时时升高了64%（p<0.004）。本研究表明，托吡酯可使健康个体的脑内GABA浓度显著升高。