Holland M, Boring J G, Boyle C R, Pickrum H M, Jeffcoat M K
College of Veterinary Medicine, Mississippi State University, Mississippi State 39762-9825, USA.
Vet Radiol Ultrasound. 1998 Jul-Aug;39(4):366-74. doi: 10.1111/j.1740-8261.1998.tb01622.x.
The goal of this study was to develop an animal model for the study of acute periodontal disease using silk ligatures in combination with a soft diet in eleven purebred beagle dogs. The silk ligatures were placed subgingivally on the mandible second and fourth premolar on one side of the mouth; the opposite side served as a control. Dogs were monitored during the 16-20 weeks of ligature placement, and for 48 weeks after ligature removal. Development of periodontal disease was evaluated by radiopharmaceutical uptake into bone, radiographic evidence of alveolar bone loss, attachment loss, gingival index and prostaglandin level. Bone loss occurred on the ligatured side during the ligature phase of the study. Radiopharmaceutical uptake was correlated with radiographic evidence of bone loss during the ligature phase. No significant bone loss occurred during the post-ligature phase. Progressive periodontal disease was induced during ligature placement. However, a chronic less aggressive form was not sustained by soft diet alone after ligature removal.
本研究的目的是利用丝线结扎并结合软食，在11只纯种比格犬中建立一种用于研究急性牙周病的动物模型。丝线结扎置于一侧下颌第二和第四前磨牙的龈下；另一侧作为对照。在结扎放置的16 - 20周期间以及结扎去除后的48周内对犬进行监测。通过放射性药物摄取到骨内、牙槽骨吸收的影像学证据、附着丧失、牙龈指数和前列腺素水平来评估牙周病的发展。在研究的结扎阶段，结扎侧出现骨吸收。在结扎阶段，放射性药物摄取与骨吸收的影像学证据相关。在结扎后阶段未发生明显的骨吸收。在结扎放置期间诱发了进行性牙周病。然而，结扎去除后仅靠软食并不能维持慢性低侵袭性的牙周病形式。
