脑脊液中的5-羟吲哚乙酸。一种生化自杀预测指标？
5-HIAA in the cerebrospinal fluid. A biochemical suicide predictor?
作者信息
Asberg M, Träskman L, Thorén P
出版信息
Arch Gen Psychiatry. 1976 Oct;33(10):1193-7. doi: 10.1001/archpsyc.1976.01770100055005.
Abstract
The incidence of suicidal acts was studied in 68 depressed patients and related to the level of 5-hydroxyindoleacetic acid (5-HIAA) in the cerebrospinal fluid. The distribution of 5-HIAA levels was bimodal. Patients in the low 5-HIAA mode (below 15 ng/ml) attempted suicide significantly more often than those in the high mode, and they used more violent means. Two of the 20 patients in the low mode, and none of the 48 patients in the high mode died from suicide.
摘要
对68名抑郁症患者的自杀行为发生率进行了研究，并将其与脑脊液中5-羟吲哚乙酸（5-HIAA）的水平相关联。5-HIAA水平的分布呈双峰状。5-HIAA水平处于低模式（低于15纳克/毫升）的患者自杀未遂的频率明显高于高模式的患者，而且他们使用的手段更暴力。低模式的20名患者中有2人自杀死亡，高模式的48名患者中无人自杀死亡。
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