Department of Clinical Neuroscience/Psychiatry, Karolinska Institutet, Karolinska University Hospital, Solna, Stockholm, Sweden.
Psychiatry Res. 2010 Jun 30;178(1):217-9. doi: 10.1016/j.psychres.2008.07.020. Epub 2010 May 8.
Associations between suicide, violent behaviour and both hypocholesterolaemia and low 5-hydroxyindolacetic acid (5-HIAA) in the cerebrospinal fluid (CSF) have been suggested. The relationships between lipids, the serotonergic system, suicidal and aggressive behaviors are complex. We explored relationships between serum cholesterol, CSF 5-HIAA, the planning subscale of suicide intent and violence of attempted suicide method in 13 medication-free male suicide attempters and eight healthy volunteers. Serum high-density lipoprotein cholesterol (HDL-C) levels were significantly lower in suicide attempters than in controls. HDL-C showed a significant positive correlation with the planning subscale of suicide intent in non-violent suicide attempters. A positive association was observed between CSF 5-HIAA and serum cholesterol in suicides. The role of cholesterol may be different in planned non-violent suicide attempts compared with violent suicide attempts.
自杀、暴力行为与脑脊液（CSF）中胆固醇降低和 5-羟吲哚乙酸（5-HIAA）降低有关。脂类、5-羟色胺能系统、自杀和攻击行为之间的关系很复杂。我们探讨了血清胆固醇、CSF 5-HIAA、自杀意图计划量表和 13 例未服药男性自杀未遂者及 8 例健康志愿者的自杀方法的暴力行为之间的关系。自杀未遂者的血清高密度脂蛋白胆固醇（HDL-C）水平明显低于对照组。在非暴力自杀未遂者中，HDL-C 与自杀意图计划量表呈显著正相关。在自杀者中，CSF 5-HIAA 与血清胆固醇之间存在正相关。胆固醇的作用在有计划的非暴力自杀企图与暴力自杀企图之间可能不同。
