阿尔茨海默病作为神经元自养缺陷：与业余无线电操作的假设类比。
Alzheimer's disease as a defect of neuronal autotrophism: a hypothetical analogy with amateur radio operation.
作者信息
Baik T K, Leech R W, Brumback R A
机构信息
Department of Anatomy, Hanyang University, College of Medicine, Seoul, Korea.
出版信息
Med Hypotheses. 1998 Jun;50(6):515-20. doi: 10.1016/s0306-9877(98)90274-2.
Amyloid precursor protein appears to be a signaling protein that plays a role in neuronal autotrophism, indicating integrity of the nerve terminal and synapse. Analogous to amateur radio operation with a damaged antenna in which further attempts to improve signal propagation can result in damage to the radio equipment, abnormal signaling by the secreted amyloid precursor protein stimulates compensatory metabolic activity in the neuron that ultimately leads to paired helical filament formation (neurofibrillary tangles) and further neuronal dysfunction and death.
淀粉样前体蛋白似乎是一种信号蛋白，在神经元自养中发挥作用，表明神经末梢和突触的完整性。这类似于天线受损的业余无线电操作，在这种情况下，进一步尝试改善信号传播可能会损坏无线电设备，分泌的淀粉样前体蛋白的异常信号传导会刺激神经元中的代偿性代谢活动，最终导致双螺旋丝形成（神经原纤维缠结）以及进一步的神经元功能障碍和死亡。
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