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Alzheimer's disease: the amyloid cascade hypothesis.

作者信息

Hardy J A, Higgins G A

机构信息

Department of Biochemistry, St. Mary's Hospital Medical School, London, U.K.

出版信息

Science. 1992 Apr 10;256(5054):184-5. doi: 10.1126/science.1566067.

DOI:10.1126/science.1566067
PMID:1566067
Abstract
摘要

相似文献

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Alzheimer's disease: the amyloid cascade hypothesis.阿尔茨海默病：淀粉样蛋白级联假说
Science. 1992 Apr 10;256(5054):184-5. doi: 10.1126/science.1566067.
2
Amyloid precursor protein (APP) and beta A4 amyloid in the etiology of Alzheimer's disease: precursor-product relationships in the derangement of neuronal function.淀粉样前体蛋白（APP）与β淀粉样蛋白A4在阿尔茨海默病病因学中的作用：神经元功能紊乱中的前体-产物关系
Brain Pathol. 1991 Jul;1(4):241-51. doi: 10.1111/j.1750-3639.1991.tb00667.x.
3
Has the amyloid cascade hypothesis for Alzheimer's disease been proved?阿尔茨海默病的淀粉样蛋白级联假说已得到证实吗？
Curr Alzheimer Res. 2006 Feb;3(1):71-3. doi: 10.2174/156720506775697098.
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Amyloid deposition as the central event in the aetiology of Alzheimer's disease.淀粉样蛋白沉积是阿尔茨海默病病因中的核心事件。
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Alzheimer's disease neuropathology. Current status of interpretation of lesion development.阿尔茨海默病神经病理学。病变发展解释的现状。
Ann N Y Acad Sci. 1992 Dec 26;673:270-84. doi: 10.1111/j.1749-6632.1992.tb27463.x.
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Molecular pathology of Alzheimer's disease in sporadic and familial Alzheimer's disease with mutations in the amyloid precursor protein.散发性阿尔茨海默病以及淀粉样前体蛋白发生突变的家族性阿尔茨海默病的分子病理学
Biochem Soc Trans. 1992 Aug;20(3):642-5. doi: 10.1042/bst0200642.
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Cell biology of the amyloid beta-protein precursor and the mechanism of Alzheimer's disease.淀粉样β蛋白前体的细胞生物学与阿尔茨海默病的发病机制
Annu Rev Cell Biol. 1994;10:373-403. doi: 10.1146/annurev.cb.10.110194.002105.
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Processing of the Alzheimer's disease beta A4 amyloid protein precursor (APP).阿尔茨海默病βA4淀粉样蛋白前体（APP）的加工过程。
Brain Pathol. 1991 Jul;1(4):253-62. doi: 10.1111/j.1750-3639.1991.tb00668.x.
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Accelerated amyloid deposition, neurofibrillary degeneration and neuronal loss in double mutant APP/tau transgenic mice.APP/tau双突变转基因小鼠中淀粉样蛋白沉积加速、神经原纤维变性及神经元丢失。
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Toward a remembrance of things past: deciphering Alzheimer disease.走向对往昔之事的追忆：解读阿尔茨海默病
Harvey Lect. 2003;99:23-45.

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