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通过小鼠肿瘤-破伤风试验测定马抗人生长激素血清对皮下艾氏癌的抑制作用。

Inhibition of subcutaneous Ehrlich carcinoma by antihuman-somatotropic hormone serum of the horse as determined by the tumour-tetanus assay of the mouse.

作者信息

Lazarev A F, Schneeweiss U, Fabricius E M

出版信息

Arch Geschwulstforsch. 1976;46(4):261-70.

PMID:971044
Abstract

Utilizing a quantitative tumour tetanus assay of the mouse it could be shown that antisomatotropic hormone serum of the horse exerts protective effects against solid Ehrlich carcinoma of the subcutaneous tissue and concomitantly, against tetanus mortality rates as an indicator of tumour growth. The positive correlation of the inhibitory action of antisomatotropic hormone serum against both transplantable tumour cells and subcutaneous regenerative tissue as a control lends further support to the assumption that a selective mechanism interrelates proliferative mammalian cell populations and multiplying toxinogenic clostridia, thus stimulating a new field of application of antisomatotropic hormone serum.

摘要

利用小鼠定量肿瘤破伤风试验可以表明,马的抗促生长激素血清对皮下组织的实体艾氏癌具有保护作用,同时,作为肿瘤生长指标的破伤风死亡率也有所降低。抗促生长激素血清对可移植肿瘤细胞和作为对照的皮下再生组织的抑制作用呈正相关,这进一步支持了以下假设:一种选择性机制将哺乳动物增殖细胞群体与繁殖产毒素梭菌联系起来,从而开拓了抗促生长激素血清的新应用领域。

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