Wand H, Rieche K, Rudolf J, Pescheck C, Grünhagen H, Binder M, Kleinwächter A
Arch Geschwulstforsch. 1976;46(4):304-10.
The effect of methylglyoxal-bis-guanylhydrazone has been studied on the electrophoretic mobility of blood cells of 10 unselected and untreated patients with preferably solid malignant diseases. Prior to the incubation with CH3-G the electrophoretic mobility of lymphocytes and erythrocytes showed increased and of platelets showed decreased rates which extend over a larger range than usual and for which reasons cannot be given till now. The incubation with CH3-G caused a concentration-dependent reduction of the electrophoretic mobility of all three tested types of blood cells. This can be estimated as an impairment of a function of surface membrane and confirms recently obtained results of activity of CH3-G on platelets' surface membrane.
已对10例未经挑选且未治疗的、主要患有实体恶性疾病的患者血细胞进行研究，观察了丙酮醛双脒腙的作用。在用CH3-G孵育之前，淋巴细胞和红细胞的电泳迁移率显示增加，而血小板的电泳迁移率显示降低，且降低幅度比通常情况更大，目前尚无法解释其原因。用CH3-G孵育导致所有三种受试血细胞的电泳迁移率呈浓度依赖性降低。这可被视为表面膜功能受损，并证实了最近所获得的CH3-G对血小板表面膜活性的研究结果。
