Juchau M R, Boutelet-Bochan H, Huang Y
Department of Pharmacology, School of Medicine, University of Washington, Seattle 98195, USA.
Drug Metab Rev. 1998 Aug;30(3):541-68. doi: 10.3109/03602539808996324.
Profound species differences and developmental stage differences as well as a lack of solid data prevent broad, sweeping generalizations in terms of statements that can be made concerning the prenatal expression of individual P450 isoforms. It is clear, however, that several of such isoforms are expressed at levels that can be toxicologically significant. At present, the greatest interest appears to be in P450s 1A1, 1B1, 2E1, and 3A7, each of which has been reported to be expressed at toxicologically significant levels or at least at potentially toxicologically significant levels during organogenesis. Reports of the expression of other P450 isoforms at later stages of gestation also have appeared in the recent literature.
物种差异和发育阶段差异巨大，且缺乏确凿数据，这使得在阐述个体细胞色素P450同工酶的产前表达时，难以做出广泛、一概而论的概括。然而，很明显，其中一些同工酶的表达水平在毒理学上具有重要意义。目前，人们似乎对细胞色素P450 1A1、1B1、2E1和3A7最为关注，据报道，在器官发生过程中，每一种同工酶的表达水平在毒理学上都具有重要意义，或者至少在潜在毒理学上具有重要意义。关于其他细胞色素P450同工酶在妊娠后期表达的报道也出现在最近的文献中。
