唐氏综合征成年患者心脏瓣膜异常的超声心动图评估
Echocardiographic evaluation of cardiac valvular abnormalities in adults with Down's syndrome.
作者信息
Hamada T, Gejyo F, Koshino Y, Murata T, Omori M, Nishio M, Misawa T, Isaki K
机构信息
Department of Clinical and Laboratory Medicine, Fukui Medical University, Japan.
出版信息
Tohoku J Exp Med. 1998 May;185(1):31-5. doi: 10.1620/tjem.185.31.
It is well known that congenital heart abnormalities are common in children with Down's syndrome. However there are few studies on cardiac abnormalities in adults with Down's syndrome. Therefore, we estimated cardiac abnormalities by means of echocardiography in 30 institutionalized Japanese adults with Down's syndrome, but without cardiac symptoms. Two-dimensional echocardiography showed an incidence of 26.7% in mitral valve prolapse and 20% increase of echo brightness in the mitral valve. Doppler echocardiography revealed an incidence of 16.7% in mitral valve regurgitation, and 13.3% in aortic valve regurgitation. Thus, even adults with Down's syndrome who are apparently free of cardiac symptoms may be at risk for valvular disease.
众所周知，先天性心脏异常在唐氏综合征患儿中很常见。然而，关于唐氏综合征成年患者心脏异常的研究却很少。因此，我们通过超声心动图对30名住在福利院的日本成年唐氏综合征患者进行了心脏异常评估，这些患者均无心脏症状。二维超声心动图显示二尖瓣脱垂的发生率为26.7%，二尖瓣回声亮度增加20%。多普勒超声心动图显示二尖瓣反流的发生率为16.7%，主动脉瓣反流的发生率为13.3%。因此，即使是明显没有心脏症状的唐氏综合征成年患者也可能有瓣膜疾病的风险。
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