Seshia S S, Rjani K R, Boeckx R L, Chow P N
Dev Med Child Neurol. 1978 Jun;20(3):323-34. doi: 10.1111/j.1469-8749.1978.tb15222.x.
Abnormal neurological signs were found in 46 of 50 children and adolescents chronically sniffing leaded gasoline. These abnormalities resolved within eight weeks in all but one case. Exaggerated deep reflexes, postural tremor and evidence of cerebellar dysfunction occurred in a highly significnat number of patients. Forty-nine had blood lead levels greater than or equal to 40ug/dl. The mean blood lead levels were significantly higher in those with (a) abnormally brisk deep reflexes and (b) with evidence of cerebellar dysfunction, than in those without these findings. Five optional treatment regimes were employed and a classification was used, based on clinical findings, initial blood lead levels and the response to the calcium disodium edatate mobilization test. 39 patients received chelation therapy. These data suggest that neurological manifestations occur frequently in those abusing leaded gasoline and that chelation therapy has an important place in their management.
在50名长期嗅闻含铅汽油的儿童和青少年中，46人出现了异常神经体征。除1例之外，所有这些异常在8周内均得到缓解。大量患者出现了深反射亢进、姿势性震颤以及小脑功能障碍的迹象。49人的血铅水平大于或等于40微克/分升。有（a）深反射异常活跃和（b）有小脑功能障碍迹象的患者，其平均血铅水平显著高于无这些表现的患者。采用了五种可选治疗方案，并根据临床发现、初始血铅水平以及对依地酸钙钠动员试验的反应进行分类。39名患者接受了螯合疗法。这些数据表明，滥用含铅汽油者经常出现神经学表现，螯合疗法在其治疗中具有重要地位。
