Sato K, Dohi Y, Miyagawa K, Kojima M
Second Department of Internal Medicine, Nagoya City University Hospital, Japan.
Jpn Heart J. 1998 May;39(3):347-53. doi: 10.1536/ihj.39.347.
The study was designed to investigate whether the acute antihypertensive effects of calcium channel blockers are affected by calcium supplementation in patients with essential hypertension. The antihypertensive effects of calcium channel blockers (oral manidipine or intravenous nicardipine) were studied before and during calcium supplementation (1200 mg/day for 8 weeks) in 30 hospitalized patients with essential hypertension. The averages of systolic and diastolic blood pressure during a 24-hour period were not decreased by calcium supplementation. The acute antihypertensive effects of the calcium channel blockers nicardipine (0.25, 0.5, 1.5, 2.0 micrograms/kg/min, intravenous infusion) or manidipine (20 mg, once a day, orally) were not enhanced by calcium supplementation. Thus, calcium channel blockers can be safely combined with calcium supplementation in terms of blood pressure.
本研究旨在调查原发性高血压患者补充钙剂是否会影响钙通道阻滞剂的急性降压效果。在30例住院的原发性高血压患者中，研究了补充钙剂（每天1200毫克，共8周）之前及期间钙通道阻滞剂（口服马尼地平或静脉注射尼卡地平）的降压效果。补充钙剂后，24小时期间的收缩压和舒张压平均值并未降低。补充钙剂并未增强钙通道阻滞剂尼卡地平（0.25、0.5、1.5、2.0微克/千克/分钟，静脉输注）或马尼地平（20毫克，每日一次，口服）的急性降压效果。因此，就血压而言，钙通道阻滞剂可安全地与钙剂联合使用。
